#1: DUTCH is a comprehensive test of hormones using dried urine.
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#2: Adrenal related symptoms can be explored with DUTCH.
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#3: ___________ is the precursor molecule that gets turned into Pregnenolone.
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#4: ___________ is required for conversion of Cholesterol to Pregnenolone.
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#5: The adrenal cortex has 4 zones.
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#6: ___________ is the outer layer of the adrenal cortex.
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#7: ___________ best reflects adrenal hormone tissue levels.
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#8: CRH stimulates the adrenal glands to make hormones.
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#9: Inflammation causes the brain to release ACTH.
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#10: ____________ converts active cortisol into inactive cortisone.
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#11: Heat shock proteins regulate cortisol binding to cell receptors
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#12: HS70 and HS90 are heat shock proteins.
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#13: Which is correct?
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#14: ____________ is made in the adrenal gland.
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#15: Sources of Heat Shock Proteins are;
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#16: __________ is inactive.
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#17: There are four main Cortisol Patterns.
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#18: High cortisone and high metabolites equals overall high free cortisol production.
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#19: Low cortisol metabolites and low cortisone is ___________.
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#20: High cortisone, low or normal cortisol metabolites with sluggish metabolism and clearance is ____________.
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#21: Normal or high cortisol metabolites with elevated clearances, obesity, hyperthyroid, long term stress and steroid use is ____________.
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#22: Cortisone can be reactivated to cortisol in liver and fat cells.
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#23: With Cortisol Awakening Response it is best to collect on a day when sleep has been disturbed.
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#24: CAR is Cortisol Awakening Response.
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#25: CAR evaluates the Cortisol Pattern in what hour of the day?
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#26: When collecting the sample for CAR it is important to ____________.
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#27: Collection Timing for CAR is not important.
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#28: Major depressive disorder, overactive HPA axis, anticipatory stress for the day, glycemic dysregulation and pain upon awakening are causes of ___________.
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#29: HPA axis health is correlated with the magnitude of the morning cortisol increase.
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#30: When interpreting CAR, ___________ blocks deactivation of cortisol to cortisone.
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#31: Low Cortisol Awakening Response may be caused by all except:
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#32: Thyroid directly impacts cortisol clearance.
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#33: The following sex hormone conditions can be explored with DUTCH.
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#34: The primary role of progesterone is to balance the strong effects of estrogen.
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#35: When evaluating estrogen levels, it is important to assess ____________.
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#36: The ________ phase I pathway is considered the safest because of anti-cancer properties of its metabolites.
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#37: The _______ phase I pathway is considered the most genotoxic as its metabolites can create reactive products that damage DNA.
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#38: Bone loss is a low estrogen symptom.
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#39: Low methylation can be caused by low levels of nutrients needed for methylation and/or genetic abnormalities.
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#40: ________ are genetic abnormalities that cause low methylation.
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#41: The COMT enzyme responsible for methylation requires _______________.
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#42: These deficiencies can cause low levels of methyl donors.
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#43: Regarding Phase II Metabolism, MTHFR genetic defects can make it more difficult for patients to make sufficient methyl donors.
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#44: When evaluating androgen levels, it is important to assess the status of __________.
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#45: DHEA significantly increases with age.
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#46: Females make most of their DHEA in the adrenal gland.
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#47: A female with higher levels of DHEA and testosterone will often have high androgen symptoms.
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#48: Women with high androgens may develop facial hair and thinning scalp hair.
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#49: Organic acid markers can be explored with DUTCH test.
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#50: Organic acid functional marker of vitamin B12 status
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#51: Organic acid functional marker of vitamin b6
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#52: Organic acid functional marker of glutathione deficiency
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#53: Primary metabolite of dopamine
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#54: Primary metabolite of norepinephrine and epinephrine
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#55: Fatigue, brain fog, memory problems, muscle weakness, unsteady gait, numbness, tingling, depression, migraines and low blood pressure.
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#56: Methylmalonic acid increases with low levels of cellular B12.
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#57: Required by the liver for tryptophan conversion to NAD.
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#58: High estrogen or cortisol may increase the need for B6.
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#59: Kynurenic acid is created when B6 is deficient.
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#60: Which is true?
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#61: If the body cannot convert pyroglutamate forward, it will show up elevated in the urine.
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#62: _____________ is a marker for glutathione deficiency.
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#63: Causes of elevated Homovanillate are:
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#64: In the presence of elevated HVA, patients may experience which of these symptoms?
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#65: Sinemet, Levodopa, Wellbutrin, and Caffeine elevate HVA.
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#66: COMT and MAO are needed to make VMA from norepinephrine.
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#67: Addictions, cravings, low blood pressure, low muscle tone, intolerance to exercise, loss of alertness
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#68: Aggression, violence, impatience, paranoia, high blood pressure, and heart palpitations
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#69: When VMA is low, assess for symptoms of low Norepinephrine and Epinephrine.
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#70: When VMA is high, assess for symptoms of excess Norepinephrine and Epinephrine.
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#71: Medications do not affect HVA.
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#72: If Homovanillate and Vanilmandelate are extremely high, it may be necessary to rule out a neuroblastic tumor.
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#73: Melatonin is mainly made in the ____________.
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#74: _____________ is associated with the circadian rhythm of all hormones.
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#75: Insomnia, increased perception of pain, poor immune response, mold exposure, constipation, increased appetite
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#76: Marker for estimating DNA damage due to oxidative stress.
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#77: Chronic inflammation, chronic stress, kidney disease, chronic liver disease, breast cancer, prostate cancer, hypertension, Parkinson’s
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#78: ______ is required for the liver to convert Tryptophan to NAD.
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#79: Low homovanillate may be caused by:
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#80: Conversion of dopamine to HVA requires sufficient SAM, Magnesium, FAD, and NAD.
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